| 9/4/2010 | Elon Phoenix 27 @ Duke 41 | |
| 9/11/2010 | Duke 48 @ Wake Forest Demon Deacons 54 | † |
| 9/18/2010 | Alabama Crimson Tide 62 @ Duke 13 | |
| 9/25/2010 | Army Black Knights 35 @ Duke 21 | |
| 10/2/2010 | Duke 16 @ Maryland Terrapins 21 | † |
| 10/16/2010 | Miami-Florida Hurricanes 28 @ Duke 13 | † |
| 10/23/2010 | Duke 7 @ Virginia Tech Hokies 44 | † |
| 10/30/2010 | Duke 34 @ Navy Midshipmen 31 | |
| 11/6/2010 | Virginia Cavaliers 48 @ Duke 56 | † |
| 11/13/2010 | Boston College Eagles 21 @ Duke 16 | † |
| 11/20/2010 | Duke 20 @ Georgia Tech Yellow Jackets 30 | † |
| 11/27/2010 | North Carolina Tar Heels 24 @ Duke 19 | † |