| 9/2/2010 | Marshall 7 @ Ohio State Buckeyes 45 | |
| 9/10/2010 | West Virginia Mountaineers 24 @ Marshall 21 1OT | |
| 9/18/2010 | Marshall 28 @ Bowling Green Falcons 44 | |
| 9/25/2010 | Ohio Bobcats 23 @ Marshall 24 | |
| 10/2/2010 | Marshall 16 @ Southern Miss Golden Eagles 41 | † |
| 10/13/2010 | UCF Knights 35 @ Marshall 14 | † |
| 10/23/2010 | Marshall 10 @ East Carolina Pirates 37 | † |
| 10/30/2010 | UTEP Miners 12 @ Marshall 16 | † |
| 11/6/2010 | Marshall 31 @ UAB Blazers 17 | † |
| 11/13/2010 | Memphis Tigers 13 @ Marshall 28 | † |
| 11/20/2010 | Marshall 17 @ SMU Mustangs 31 | † |
| 11/27/2010 | Tulane Green Wave 23 @ Marshall 38 | † |