| 9/4/2010 | Wofford Terriers 10 @ Ohio 33 | |
| 9/11/2010 | Toledo Rockets 20 @ Ohio 13 | † |
| 9/18/2010 | Ohio 7 @ Ohio State Buckeyes 43 | |
| 9/25/2010 | Ohio 23 @ Marshall Thundering Herd 24 | |
| 10/2/2010 | Ohio 30 @ Eastern Michigan Eagles 17 | † |
| 10/9/2010 | Bowling Green Falcons 25 @ Ohio 49 | † |
| 10/16/2010 | Akron Zips 10 @ Ohio 38 | † |
| 10/23/2010 | Ohio 34 @ Miami-Ohio Redhawks 13 | † |
| 10/30/2010 | UL Lafayette Ragin' Cajuns 31 @ Ohio 38 | |
| 11/4/2010 | Buffalo Bulls 17 @ Ohio 34 | † |
| 11/16/2010 | Ohio 31 @ Temple Owls 23 | † |
| 11/26/2010 | Ohio 6 @ Kent State Golden Flashes 28 | † |
| 12/18/2010 | Ohio 21 vs Troy Trojans 48 (New Orleans - New Orleans Bowl) |