| 9/4/2010 | Connecticut Huskies 10 @ Michigan 30 | |
| 9/11/2010 | Michigan 28 @ Notre Dame Fighting Irish 24 | |
| 9/18/2010 | Massachusetts Minutemen 37 @ Michigan 42 | |
| 9/25/2010 | Bowling Green Falcons 21 @ Michigan 65 | |
| 10/2/2010 | Michigan 42 @ Indiana Hoosiers 35 | † |
| 10/9/2010 | Michigan State Spartans 34 @ Michigan 17 | † |
| 10/16/2010 | Iowa Hawkeyes 38 @ Michigan 28 | † |
| 10/30/2010 | Michigan 31 @ Penn State Nittany Lions 41 | † |
| 11/6/2010 | Illinois Fighting Illini 65 @ Michigan 67 3OT | † |
| 11/13/2010 | Michigan 27 @ Purdue Boilermakers 16 | † |
| 11/20/2010 | Wisconsin Badgers 48 @ Michigan 28 | † |
| 11/27/2010 | Michigan 7 @ Ohio State Buckeyes 37 | † |
| 1/1/2011 | Mississippi State Bulldogs 52 vs Michigan 14 (Jacksonville - Gator Bowl) |