| 9/4/2010 | Syracuse Orangemen 29 @ Akron 3 | |
| 9/11/2010 | Gardner-Webb Runnin' Bulldogs 38 @ Akron 37 1OT | |
| 9/18/2010 | Akron 10 @ Kentucky Wildcats 47 | |
| 9/25/2010 | Akron 20 @ Indiana Hoosiers 35 | |
| 10/2/2010 | Northern Illinois Huskies 50 @ Akron 14 | † |
| 10/9/2010 | Akron 17 @ Kent State Golden Flashes 28 | † |
| 10/16/2010 | Akron 10 @ Ohio Bobcats 38 | † |
| 10/23/2010 | Western Michigan Broncos 56 @ Akron 10 | † |
| 10/30/2010 | Akron 0 @ Temple Owls 30 | † |
| 11/6/2010 | Akron 30 @ Ball State Cardinals 37 2OT | † |
| 11/17/2010 | Miami-Ohio Redhawks 19 @ Akron 14 | † |
| 11/26/2010 | Buffalo Bulls 14 @ Akron 22 | † |