| 9/4/2010 | Kentucky 23 @ Louisville Cardinals 16 | |
| 9/11/2010 | Western Kentucky Hilltoppers 28 @ Kentucky 63 | |
| 9/18/2010 | Akron Zips 10 @ Kentucky 47 | |
| 9/25/2010 | Kentucky 14 @ Florida Gators 48 | † |
| 10/2/2010 | Kentucky 35 @ Mississippi Rebels 42 | † |
| 10/9/2010 | Auburn Tigers 37 @ Kentucky 34 | † |
| 10/16/2010 | South Carolina Gamecocks 28 @ Kentucky 31 | † |
| 10/23/2010 | Georgia Bulldogs 44 @ Kentucky 31 | † |
| 10/30/2010 | Kentucky 17 @ Mississippi State Bulldogs 24 | † |
| 11/6/2010 | Charleston Southern Buccaneers 21 @ Kentucky 49 | |
| 11/13/2010 | Vanderbilt Commodores 20 @ Kentucky 38 | † |
| 11/27/2010 | Kentucky 14 @ Tennessee Volunteers 24 | † |
| 1/8/2011 | Pittsburgh Panthers 27 vs Kentucky 10 (Birmingham - BBVA Compass Bowl) |