| 9/4/2010 | Hampden-Sydney @ Averett | |
| 9/4/2010 | Emory & Henry @ Ferrum | |
| 9/4/2010 | Washington and Lee @ Franklin & Marshall | |
| 9/4/2010 | Greensboro @ Guilford | |
| 9/4/2010 | Randolph-Macon @ Methodist | |
| 9/4/2010 | Catholic @ Shenandoah | |
| 9/4/2010 | Bridgewater VA @ St Vincent | |
| 9/11/2010 | Shenandoah @ Bridgewater VA | |
| 9/11/2010 | Apprentice @ Catholic | |
| 9/11/2010 | Emory & Henry @ Greensboro | |
| 9/11/2010 | Methodist @ Guilford | |
| 9/11/2010 | North Carolina Wesleyan @ Hampden-Sydney | |
| 9/11/2010 | Johns Hopkins @ Randolph-Macon | |
| 9/11/2010 | Washington and Lee @ Sewanee | |
| 9/18/2010 | Guilford @ Averett | |
| 9/18/2010 | McDaniel @ Catholic | |
| 9/18/2010 | Virginia-Wise @ Emory & Henry | |
| 9/18/2010 | Sewanee @ Hampden-Sydney | |
| 9/18/2010 | Shenandoah @ Randolph-Macon | |
| 9/25/2010 | Catholic @ Albright | |
| 9/25/2010 | Ferrum @ Bridgewater VA | |
| 9/25/2010 | Methodist @ Emory & Henry | |
| 9/25/2010 | Frostburg State @ Randolph-Macon | |
| 9/25/2010 | Hampden-Sydney @ Salisbury | |
| 9/25/2010 | Averett @ Washington and Lee | |
| 9/30/2010 | Southern Virginia vs Bridgewater VA | |
| 10/2/2010 | Hampden-Sydney @ Catholic | † |
| 10/2/2010 | Randolph-Macon @ Emory & Henry | † |
| 10/2/2010 | Washington and Lee @ Guilford | † |
| 10/9/2010 | Hampden-Sydney @ Bridgewater VA | † |
| 10/9/2010 | Catholic @ Randolph-Macon | † |
| 10/9/2010 | Guilford @ Southern Virginia | |
| 10/9/2010 | Emory & Henry @ Washington and Lee | † |
| 10/16/2010 | Bridgewater VA @ Guilford | † |
| 10/16/2010 | Emory & Henry @ Hampden-Sydney | † |
| 10/16/2010 | Randolph-Macon @ Washington and Lee | † |
| 10/23/2010 | Washington and Lee @ Bridgewater VA | † |
| 10/23/2010 | Catholic @ Emory & Henry | † |
| 10/23/2010 | Guilford @ Randolph-Macon | † |
| 10/29/2010 | Washington and Lee @ Catholic | † |
| 10/30/2010 | Emory & Henry @ Bridgewater VA | † |
| 10/30/2010 | Guilford @ Hampden-Sydney | † |
| 11/6/2010 | Catholic @ Guilford | † |
| 11/6/2010 | Bridgewater VA @ Randolph-Macon | † |
| 11/6/2010 | Hampden-Sydney @ Washington and Lee | † |
| 11/13/2010 | Bridgewater VA @ Catholic | † |
| 11/13/2010 | Guilford @ Emory & Henry | † |
| 11/13/2010 | Randolph-Macon @ Hampden-Sydney | † |
| 11/13/2010 | Washington and Lee @ Juniata |