| 9/4/2010 | Sewanee 33 @ Earlham Hustlin' Quakers 14 | |
| 9/11/2010 | Washington and Lee Generals 48 @ Sewanee 17 | |
| 9/18/2010 | Sewanee 0 @ Hampden-Sydney Tigers 38 | |
| 9/25/2010 | Sewanee 7 @ DePauw Tigers 35 | † |
| 10/2/2010 | Centre Praying Colonels 64 @ Sewanee 13 | † |
| 10/9/2010 | Sewanee 17 @ Austin Kangaroos 34 | † |
| 10/16/2010 | Trinity TX Tigers 17 @ Sewanee 3 | † |
| 10/23/2010 | Sewanee 10 @ Birmingham-Southern Panthers 50 | † |
| 10/30/2010 | Sewanee 0 @ Millsaps Majors 30 | † |
| 11/13/2010 | Rhodes Lynx 20 @ Sewanee 16 | † |