| 9/4/2010 | Catholic Cardinals 16 @ Shenandoah 13 | |
| 9/11/2010 | Shenandoah 31 @ Bridgewater VA Eagles 38 | |
| 9/18/2010 | Shenandoah 14 @ Randolph-Macon Yellow Jackets 42 | |
| 10/2/2010 | Christopher Newport Captains 28 @ Shenandoah 13 | † |
| 10/9/2010 | Shenandoah 7 @ Maryville Saints 6 | † |
| 10/16/2010 | Methodist Monarchs 18 @ Shenandoah 21 | † |
| 10/23/2010 | Shenandoah 20 @ Ferrum Panthers 56 | † |
| 10/30/2010 | Averett Cougars 14 @ Shenandoah 24 | † |
| 11/6/2010 | North Carolina Wesleyan Battling Bishops 38 @ Shenandoah 0 | † |
| 11/13/2010 | Shenandoah 44 @ Greensboro Pride 16 | † |