| 9/4/2010 | Bridgewater VA Eagles 19 @ St Vincent 14 | |
| 9/11/2010 | St Vincent 23 @ Fairleigh Dickinson-Florham Devils 28 | |
| 9/25/2010 | Thiel Tomcats 3 @ St Vincent 17 | † |
| 10/2/2010 | Geneva Golden Tornadoes 27 @ St Vincent 23 | † |
| 10/9/2010 | St Vincent 20 @ Washington & Jefferson Presidents 31 | † |
| 10/16/2010 | St Vincent 6 @ Thomas More Saints 24 | † |
| 10/23/2010 | Grove City Wolverines 17 @ St Vincent 42 | † |
| 10/30/2010 | Waynesburg Yellow Jackets 34 @ St Vincent 28 | † |
| 11/6/2010 | St Vincent 21 @ Westminster PA Titans 14 | † |
| 11/13/2010 | St Vincent 28 @ Bethany WV Bison 35 | † |