| 9/4/2010 | North Carolina Wesleyan 7 @ Salisbury Seagulls 13 | |
| 9/11/2010 | North Carolina Wesleyan 19 @ Hampden-Sydney Tigers 21 | |
| 9/25/2010 | LaGrange Panthers 24 @ North Carolina Wesleyan 35 | |
| 10/2/2010 | North Carolina Wesleyan 24 @ Ferrum Panthers 14 | † |
| 10/9/2010 | Greensboro Pride 12 @ North Carolina Wesleyan 48 | † |
| 10/16/2010 | Christopher Newport Captains 23 @ North Carolina Wesleyan 15 | † |
| 10/23/2010 | North Carolina Wesleyan 34 @ Maryville Saints 16 | † |
| 10/30/2010 | Methodist Monarchs 6 @ North Carolina Wesleyan 56 | † |
| 11/6/2010 | North Carolina Wesleyan 38 @ Shenandoah Hornets 0 | † |
| 11/13/2010 | Averett Cougars 13 @ North Carolina Wesleyan 28 | † |