| 9/4/2010 | Emory & Henry Wasps 23 @ Ferrum 17 2OT | |
| 9/18/2010 | Southern Virginia Knights 20 @ Ferrum 17 | |
| 9/25/2010 | Ferrum 24 @ Bridgewater VA Eagles 35 | |
| 10/2/2010 | North Carolina Wesleyan Battling Bishops 24 @ Ferrum 14 | † |
| 10/9/2010 | Ferrum 51 @ Methodist Monarchs 45 3OT | † |
| 10/16/2010 | Ferrum 28 @ Greensboro Pride 20 | † |
| 10/23/2010 | Shenandoah Hornets 20 @ Ferrum 56 | † |
| 10/30/2010 | Ferrum 21 @ Christopher Newport Captains 27 | † |
| 11/6/2010 | Ferrum 34 @ Averett Cougars 13 | † |
| 11/13/2010 | Maryville Saints 23 @ Ferrum 21 | † |