| 9/4/2010 | Greensboro 17 @ Guilford Quakers 15 | |
| 9/11/2010 | Emory & Henry Wasps 28 @ Greensboro 6 | |
| 9/18/2010 | Greensboro 7 @ Apprentice Ship Builders 9 | |
| 10/2/2010 | Greensboro 0 @ Averett Cougars 50 | † |
| 10/9/2010 | Greensboro 12 @ North Carolina Wesleyan Battling Bishops 48 | † |
| 10/16/2010 | Ferrum Panthers 28 @ Greensboro 20 | † |
| 10/23/2010 | Greensboro 7 @ Christopher Newport Captains 37 | † |
| 10/30/2010 | Maryville Saints 40 @ Greensboro 6 | † |
| 11/6/2010 | Greensboro 22 @ Methodist Monarchs 19 | † |
| 11/13/2010 | Shenandoah Hornets 44 @ Greensboro 16 | † |