| 9/11/2010 | Johns Hopkins 37 @ Randolph-Macon Yellow Jackets 41 | |
| 9/18/2010 | Johns Hopkins 29 @ Gettysburg Bullets 21 | † |
| 9/25/2010 | Johns Hopkins 41 @ Moravian Greyhounds 3 | † |
| 10/2/2010 | Muhlenberg Mules 30 @ Johns Hopkins 27 | † |
| 10/8/2010 | Dickinson Red Devils 10 @ Johns Hopkins 44 | † |
| 10/16/2010 | Johns Hopkins 17 @ Ursinus Bears 26 | † |
| 10/23/2010 | Johns Hopkins 49 @ Susquehanna Crusaders 24 | † |
| 10/30/2010 | Juniata Eagles 0 @ Johns Hopkins 48 | † |
| 11/6/2010 | Johns Hopkins 24 @ Franklin & Marshall Diplomats 9 | † |
| 11/13/2010 | McDaniel Green Terror 10 @ Johns Hopkins 34 | † |
| 11/20/2010 | Lebanon Valley Flying Dutchmen 14 @ Johns Hopkins 44 (ECAC South Atlantic Bowl) |