| 9/4/2010 | McDaniel 3 @ Juniata Eagles 0 | † |
| 9/11/2010 | Moravian Greyhounds 10 @ McDaniel 13 | † |
| 9/18/2010 | McDaniel 24 @ Catholic Cardinals 14 | |
| 9/25/2010 | Dickinson Red Devils 41 @ McDaniel 16 | † |
| 10/9/2010 | Susquehanna Crusaders 0 @ McDaniel 35 | † |
| 10/16/2010 | Muhlenberg Mules 29 @ McDaniel 0 | † |
| 10/23/2010 | McDaniel 18 @ Ursinus Bears 43 | † |
| 10/30/2010 | McDaniel 28 @ Franklin & Marshall Diplomats 31 | † |
| 11/6/2010 | Gettysburg Bullets 30 @ McDaniel 36 3OT | † |
| 11/13/2010 | McDaniel 10 @ Johns Hopkins Blue Jays 34 | † |