| 9/4/2010 | Randolph-Macon Yellow Jackets 54 @ Methodist 14 | |
| 9/11/2010 | Methodist 26 @ Guilford Quakers 21 | |
| 9/25/2010 | Methodist 6 @ Emory & Henry Wasps 49 | |
| 10/2/2010 | Maryville Saints 14 @ Methodist 17 | † |
| 10/9/2010 | Ferrum Panthers 51 @ Methodist 45 3OT | † |
| 10/16/2010 | Methodist 18 @ Shenandoah Hornets 21 | † |
| 10/23/2010 | Averett Cougars 7 @ Methodist 3 | † |
| 10/30/2010 | Methodist 6 @ North Carolina Wesleyan Battling Bishops 56 | † |
| 11/6/2010 | Greensboro Pride 22 @ Methodist 19 | † |
| 11/13/2010 | Methodist 10 @ Christopher Newport Captains 49 | † |