| 9/4/2010 | North Carolina Wesleyan Battling Bishops 7 @ Salisbury 13 | |
| 9/11/2010 | Christopher Newport Captains 10 @ Salisbury 58 | |
| 9/18/2010 | Salisbury 84 @ Husson Eagles 7 | |
| 9/25/2010 | Hampden-Sydney Tigers 32 @ Salisbury 28 | |
| 10/2/2010 | Salisbury 31 @ Apprentice Ship Builders 7 | † |
| 10/16/2010 | Huntingdon AL Hawks 21 @ Salisbury 45 | |
| 10/23/2010 | Salisbury 52 @ Union NY Dutchmen 21 | |
| 10/30/2010 | Wesley Wolverines 17 @ Salisbury 14 | † |
| 11/13/2010 | Salisbury 37 @ Frostburg State Bobcats 6 | † |
| 11/20/2010 | Salisbury 12 @ Delaware Valley Aggies 23 (D3 Playoffs Round 1) |