| 9/4/2010 | Washington and Lee Generals 7 @ Franklin & Marshall 35 | |
| 9/11/2010 | Ursinus Bears 10 @ Franklin & Marshall 7 | † |
| 9/17/2010 | Franklin & Marshall 35 @ Dickinson Red Devils 26 | † |
| 9/25/2010 | Juniata Eagles 13 @ Franklin & Marshall 55 | † |
| 10/2/2010 | Franklin & Marshall 41 @ Susquehanna Crusaders 20 | † |
| 10/16/2010 | Franklin & Marshall 17 @ Moravian Greyhounds 24 | † |
| 10/23/2010 | Franklin & Marshall 17 @ Muhlenberg Mules 7 | † |
| 10/30/2010 | McDaniel Green Terror 28 @ Franklin & Marshall 31 | † |
| 11/6/2010 | Johns Hopkins Blue Jays 24 @ Franklin & Marshall 9 | † |
| 11/13/2010 | Franklin & Marshall 35 @ Gettysburg Bullets 57 | † |
| 11/20/2010 | Franklin & Marshall 41 @ Washington & Jefferson Presidents 56 (ECAC Southwest Bowl) |