| 8/27/2022 | Stephen F. Austin | 17 | vs | Jacksonville State | 42 | Montgomery AL | vs ASUN | |
| 9/1/2022 | Lamar | 14 | at | Abilene Christian | 28 | SLC | ||
| St Thomas | 13 | at | Southern Utah | 44 | Pio | |||
| Mississippi Valley State | 13 | at | Tarleton State | 29 | SWAC | |||
| 9/3/2022 | Stephen F. Austin | 31 | at | Alcorn State | 27 | @ SWAC | ||
| Utah Tech | 33 | at | Sacramento State | 56 | @ BSky | |||
| Sam Houston | 0 | at | Texas A&M | 31 | @ SEC (1A) | |||
| 9/10/2022 | Prairie View | 13 | at | Abilene Christian | 21 | SWAC | ||
| Stephen F. Austin | 17 | at | Louisiana Tech | 52 | @ CUSA (1A) | |||
| Northern Arizona | 10 | at | Sam Houston | 3 | BSky | |||
| Tarleton State | 17 | at | TCU | 59 | @ B12 (1A) | |||
| Southern Utah | 7 | at | Utah | 73 | @ P12 (1A) | |||
| Chadron State | 10 | at | Utah Tech | 56 | RMAC (D2) | |||
| 9/17/2022 | Abilene Christian | 17 | at | Missouri | 34 | @ SEC (1A) | ||
| Texas A&M-Commerce | 17 | at | Sam Houston | 27 | SLC | |||
| Eastern New Mexico | 6 | at | Tarleton State | 41 | LSC (D2) | |||
| Utah Tech | 14 | at | Weber State | 44 | @ BSky | |||
| Southern Utah | 17 | at | Western Illinois | 10 | @ MVC | |||
| 9/24/2022 | Western New Mexico | 7 | at | Abilene Christian | 34 | LSC (D2) | ||
| Tarleton State | 43 | at | North Alabama | 28 | @ ASUN | |||
| Utah Tech | 17 | at | Southern Utah | 31 | ||||
| Warner U. | 0 | at | Stephen F. Austin | 98 | Sun (NAIA) | |||
| 10/1/2022 | Southern Utah | 28 | at | Eastern Kentucky | 35 | @ ASUN | ||
| Stephen F. Austin | 16 | vs | Sam Houston | 17 | Houston TX | |||
| Abilene Christian | 26 | at | Utah Tech | 10 | ||||
| 10/8/2022 | Tarleton State | 42 | at | Southern Utah | 40 | |||
| Abilene Christian | 38 | at | Stephen F. Austin | 41 | ||||
| 10/15/2022 | Southern Utah | 18 | at | Abilene Christian | 21 | |||
| Sam Houston | 25 | at | Eastern Kentucky | 17 | @ ASUN | |||
| Utah Tech | 14 | at | Northern Iowa | 41 | @ MVC | |||
| Tarleton State | 24 | at | Stephen F. Austin | 41 | ||||
| 10/22/2022 | Stephen F. Austin | 41 | at | Southern Utah | 38 | |||
| Southwest Baptist | 10 | at | Tarleton State | 24 | GLV (D2) | |||
| Sam Houston | 18 | at | Utah Tech | 13 | ||||
| 10/29/2022 | Abilene Christian | 31 | at | North Dakota | 34 | @ MVC | ||
| Utah Tech | 47 | at | Stephen F. Austin | 44 | ||||
| Sam Houston | 40 | at | Tarleton State | 21 | ||||
| 11/5/2022 | Abilene Christian | 28 | at | Tarleton State | 23 | |||
| Southern Utah | 36 | at | Utah Tech | 48 | ||||
| 11/12/2022 | Abilene Christian | 45 | at | Sam Houston | 28 | |||
| Lincoln CA | 0 | at | Southern Utah | 55 | None (Unk?) | |||
| Central Arkansas | 34 | at | Stephen F. Austin | 7 | ASUN | |||
| Tarleton State | 28 | at | Utah Tech | 34 | ||||
| 11/19/2022 | Stephen F. Austin | 24 | at | Abilene Christian | 21 | |||
| Utah Tech | 26 | at | BYU | 52 | @ Ind (1A) | |||
| Southern Utah | 17 | at | Sam Houston | 7 | ||||
| Houston Christian | 7 | at | Tarleton State | 49 | SLC |