| 9/1/2022 | Eastern New Mexico | 34 | at | New Mexico Highlands (3-7) | 18 | at RMAC | ||
| 9/10/2022 | Midwestern State (6-5,5-4) | 28 | at | Eastern New Mexico | 14 | |||
| 9/17/2022 | Eastern New Mexico | 6 | at | Tarleton State (6-5) | 41 | at WAC | ||
| 9/24/2022 | Eastern New Mexico | 10 | at | Texas A&M-Kingsville (7-5,5-4) | 43 | |||
| 10/1/2022 | Central Washington (6-4,6-3) | 45 | at | Eastern New Mexico | 17 | |||
| 10/8/2022 | Eastern New Mexico | 9 | at | Angelo State (12-1,9-0) | 28 | |||
| 10/15/2022 | Simon Fraser (1-8,1-8) | 14 | at | Eastern New Mexico | 42 | |||
| 10/22/2022 | Eastern New Mexico | 7 | at | Western Oregon (6-5,5-4) | 46 | |||
| 10/29/2022 | Texas-Permian Basin (5-6,4-5) | 24 | at | Eastern New Mexico | 21 | |||
| 11/5/2022 | Eastern New Mexico | 24 | at | West Texas A&M (5-6,3-6) | 21 | |||
| 11/12/2022 | Western New Mexico (6-5,5-4) | 38 | at | Eastern New Mexico | 24 |
| vs Eastern New Mexico | vs Other Opponents | Eastern New Mexico compared to OOs | |
| Record: | 8-3 | 55-54 | |
| Points Scored: | 31.45 | 26.05 | -5.40 |
| Points Allowed: | 18.91 | 26.18 | -7.27 |
| Margin: | 12.54 | -0.13 | -12.67 |
| Total Points: | 50.36 | 52.23 | -1.87 |