| 9/3/2022 | Wingate | 21 | at | Shaw (4-6) | 7 | at CIAA | ||
| 9/10/2022 | Wingate | 21 | at | Fayetteville State (9-3) | 3 | at CIAA | ||
| 9/17/2022 | Wingate | 27 | at | Tusculum (8-3,6-3) | 10 | |||
| 9/24/2022 | Emory & Henry (5-6,4-5) | 17 | at | Wingate | 10 | |||
| 10/1/2022 | Wingate | 31 | at | Erskine (2-9,0-9) | 7 | |||
| 10/8/2022 | Catawba (1-10,0-9) | 0 | at | Wingate | 28 | |||
| 10/15/2022 | Wingate | 28 | at | Limestone (8-4,7-2) | 21 | |||
| 10/22/2022 | Barton (4-7,3-6) | 3 | at | Wingate | 28 | |||
| 10/29/2022 | Wingate | 24 | at | Lenoir-Rhyne (8-3,7-2) | 21 | |||
| 11/5/2022 | Newberry (9-2,7-2) | 24 | at | Wingate | 15 | |||
| 11/12/2022 | Virginia-Wise (2-9,1-8) | 7 | at | Wingate | 45 | |||
| 11/19/2022 | Wingate | 32 | at | Virginia Union (9-2) | 7 | D2 Championship Round 1 | at CIAA | |
| 11/26/2022 | Wingate | 23 | at | Benedict (11-1) | 6 | D2 Playoffs Round 2 | at SIAC | |
| 12/3/2022 | Wingate | 14 | at | West Florida (12-2) | 45 | D2 Quarterfinals | at GSC |
| vs Wingate | vs Other Opponents | Wingate compared to OOs | |
| Record: | 3-11 | 89-56 | |
| Points Scored: | 12.71 | 29.92 | 17.21 |
| Points Allowed: | 24.79 | 23.97 | 0.82 |
| Margin: | -12.08 | 5.95 | 18.03 |
| Total Points: | 37.50 | 53.89 | -16.39 |