| 9/3/2022 | Concord (9-2) | 27 | at | Emory & Henry | 20 | MtnE | ||
| 9/10/2022 | Emory & Henry | 41 | at | Bluefield (8-3) | 33 | at MSC | ||
| 9/17/2022 | Newberry (9-2,7-2) | 26 | at | Emory & Henry | 23 | 2OT | ||
| 9/24/2022 | Emory & Henry | 17 | at | Wingate (11-3,7-2) | 10 | |||
| 9/30/2022 | Catawba (1-10,0-9) | 23 | at | Emory & Henry | 38 | |||
| 10/8/2022 | Virginia-Wise (2-9,1-8) | 14 | at | Emory & Henry | 34 | |||
| 10/15/2022 | Emory & Henry | 14 | at | Mars Hill (7-3,7-2) | 49 | |||
| 10/22/2022 | Emory & Henry | 9 | at | Tusculum (8-3,6-3) | 35 | |||
| 10/29/2022 | Carson-Newman (6-5,5-4) | 21 | at | Emory & Henry | 7 | |||
| 11/5/2022 | Emory & Henry | 32 | at | Erskine (2-9,0-9) | 0 | |||
| 11/12/2022 | Emory & Henry | 27 | at | Limestone (8-4,7-2) | 45 |
| vs Emory & Henry | vs Other Opponents | Emory & Henry compared to OOs | |
| Record: | 6-5 | 65-48 | |
| Points Scored: | 25.73 | 27.73 | 2.00 |
| Points Allowed: | 23.82 | 26.04 | -2.22 |
| Margin: | 1.91 | 1.69 | -0.22 |
| Total Points: | 49.55 | 53.77 | -4.22 |