| 9/3/2022 | UNC Pembroke (5-6) | 13 | at | Fayetteville State | 15 | MtnE | ||
| 9/10/2022 | Wingate (11-3) | 21 | at | Fayetteville State | 3 | SAC | ||
| 9/17/2022 | Fayetteville State | 19 | at | Lincoln PA (2-7,1-6) | 7 | |||
| 9/24/2022 | Virginia Union (9-2,7-1) | 31 | at | Fayetteville State | 28 | |||
| 9/29/2022 | Chowan (7-4,7-2) | 10 | at | Fayetteville State | 13 | |||
| 10/8/2022 | St Augustine's (1-9,1-7) | 0 | at | Fayetteville State | 54 | |||
| 10/15/2022 | Fayetteville State | 44 | at | Livingstone (4-6,4-5) | 7 | |||
| 10/22/2022 | Fayetteville State | 21 | at | Johnson C Smith (2-7,2-6) | 13 | |||
| 10/29/2022 | Shaw (4-6,4-4) | 20 | at | Fayetteville State | 28 | |||
| 11/5/2022 | Fayetteville State | 14 | at | Winston-Salem State (3-6,3-4) | 6 | |||
| 11/12/2022 | Fayetteville State | 31 | at | Chowan (7-4,7-2) | 28 | |||
| 11/19/2022 | Fayetteville State | 0 | at | Delta State (11-2) | 51 | D2 Championship Round 1 | at GSC |
| vs Fayetteville State | vs Other Opponents | Fayetteville State compared to OOs | |
| Record: | 3-9 | 63-51 | |
| Points Scored: | 17.25 | 26.02 | 8.77 |
| Points Allowed: | 22.50 | 24.61 | -2.11 |
| Margin: | -5.25 | 1.41 | 6.66 |
| Total Points: | 39.75 | 50.63 | -10.88 |