| 9/3/2022 | Catawba | 44 | at | Livingstone (4-6) | 19 | at CIAA | ||
| 9/10/2022 | Catawba | 21 | at | Shorter (3-8) | 34 | at GSC | ||
| 9/17/2022 | Catawba | 7 | at | Mars Hill (7-3,7-2) | 38 | |||
| 9/24/2022 | Tusculum (8-3,6-3) | 50 | at | Catawba | 17 | |||
| 9/30/2022 | Catawba | 23 | at | Emory & Henry (5-6,4-5) | 38 | |||
| 10/8/2022 | Catawba | 0 | at | Wingate (11-3,7-2) | 28 | |||
| 10/15/2022 | Newberry (9-2,7-2) | 34 | at | Catawba | 27 | |||
| 10/22/2022 | Limestone (8-4,7-2) | 48 | at | Catawba | 23 | |||
| 10/29/2022 | Catawba | 21 | at | Barton (4-7,3-6) | 38 | |||
| 11/5/2022 | Lenoir-Rhyne (8-3,7-2) | 62 | at | Catawba | 10 | |||
| 11/12/2022 | Carson-Newman (6-5,5-4) | 61 | at | Catawba | 23 |
| vs Catawba | vs Other Opponents | Catawba compared to OOs | |
| Record: | 10-1 | 63-49 | |
| Points Scored: | 40.91 | 25.62 | -15.29 |
| Points Allowed: | 19.64 | 23.70 | -4.06 |
| Margin: | 21.27 | 1.92 | -19.35 |
| Total Points: | 60.55 | 49.32 | 11.23 |