| 9/3/2022 | Allen (1-8) | 6 | at | Newberry | 40 | SIAC | ||
| 9/10/2022 | Newberry | 29 | at | North Greenville (3-8) | 22 | at GSC | ||
| 9/17/2022 | Newberry | 26 | at | Emory & Henry (5-6,4-5) | 23 | 2OT | ||
| 9/24/2022 | Erskine (2-9,0-9) | 14 | at | Newberry | 32 | |||
| 10/1/2022 | Newberry | 14 | at | Carson-Newman (6-5,5-4) | 24 | |||
| 10/8/2022 | Barton (4-7,3-6) | 21 | at | Newberry | 42 | |||
| 10/15/2022 | Newberry | 34 | at | Catawba (1-10,0-9) | 27 | |||
| 10/22/2022 | Newberry | 38 | at | Lenoir-Rhyne (8-3,7-2) | 24 | |||
| 10/29/2022 | Limestone (8-4,7-2) | 42 | at | Newberry | 37 | |||
| 11/5/2022 | Newberry | 24 | at | Wingate (11-3,7-2) | 15 | |||
| 11/12/2022 | Mars Hill (7-3,7-2) | 24 | at | Newberry | 27 |
| vs Newberry | vs Other Opponents | Newberry compared to OOs | |
| Record: | 2-9 | 54-57 | |
| Points Scored: | 22.00 | 26.26 | 4.26 |
| Points Allowed: | 31.18 | 26.83 | 4.35 |
| Margin: | -9.18 | -0.57 | 8.61 |
| Total Points: | 53.18 | 53.09 | 0.09 |