| 9/1/2022 | St Augustine's (1-9) | 13 | at | Tusculum | 70 | CIAA | ||
| 9/10/2022 | Tusculum | 23 | at | Chowan (7-4) | 21 | at CIAA | ||
| 9/17/2022 | Wingate (11-3,7-2) | 27 | at | Tusculum | 10 | |||
| 9/24/2022 | Tusculum | 50 | at | Catawba (1-10,0-9) | 17 | |||
| 9/29/2022 | Tusculum | 14 | at | Barton (4-7,3-6) | 13 | |||
| 10/8/2022 | Carson-Newman (6-5,5-4) | 6 | at | Tusculum | 34 | |||
| 10/15/2022 | Tusculum | 10 | at | Virginia-Wise (2-9,1-8) | 9 | |||
| 10/22/2022 | Emory & Henry (5-6,4-5) | 9 | at | Tusculum | 35 | |||
| 10/29/2022 | Erskine (2-9,0-9) | 14 | at | Tusculum | 49 | |||
| 11/5/2022 | Tusculum | 27 | at | Mars Hill (7-3,7-2) | 34 | |||
| 11/12/2022 | Tusculum | 14 | at | Lenoir-Rhyne (8-3,7-2) | 34 |
| vs Tusculum | vs Other Opponents | Tusculum compared to OOs | |
| Record: | 3-8 | 51-60 | |
| Points Scored: | 17.91 | 23.50 | 5.59 |
| Points Allowed: | 30.55 | 25.86 | 4.69 |
| Margin: | -12.64 | -2.36 | 10.28 |
| Total Points: | 48.46 | 49.36 | -0.90 |