| 9/1/2022 | Glenville State (7-4) | 44 | at | Quincy | 15 | MtnE | ||
| 9/8/2022 | Trinity International (1-10) | 14 | at | Quincy | 53 | MSFA (NAIA) | ||
| 9/17/2022 | Quincy | 28 | at | Walsh (1-9) | 13 | at GMAC | ||
| 9/24/2022 | Ashland (10-2) | 34 | at | Quincy | 14 | GMAC | ||
| 10/1/2022 | Quincy | 24 | at | Missouri S&T (3-7,2-4) | 31 | |||
| 10/8/2022 | Kentucky Wesleyan (2-9) | 9 | at | Quincy | 46 | GMAC | ||
| 10/15/2022 | Quincy | 63 | at | McKendree (5-6,2-4) | 62 | OT | ||
| 10/22/2022 | Quincy | 38 | at | Indianapolis (9-2,6-0) | 52 | |||
| 10/29/2022 | Truman State (9-2,5-1) | 59 | at | Quincy | 32 | |||
| 11/5/2022 | Quincy | 24 | at | Southwest Baptist (6-5,4-2) | 42 | |||
| 11/12/2022 | William Jewell (2-9,1-5) | 17 | at | Quincy | 7 |
| vs Quincy | vs Other Opponents | Quincy compared to OOs | |
| Record: | 7-4 | 48-61 | |
| Points Scored: | 34.27 | 23.78 | -10.49 |
| Points Allowed: | 31.27 | 29.28 | 1.99 |
| Margin: | 3.00 | -5.50 | -8.50 |
| Total Points: | 65.54 | 53.06 | 12.48 |