| 9/1/2022 | Ferrum | 9 | at | Virginia-Wise | 41 | @ SAC (D2) | ||
| 9/3/2022 | Apprentice | 27 | at | Averett | 14 | None (Unk?) | ||
| Bridgewater VA | 29 | at | Gettysburg | 14 | @ Cen | |||
| Guilford | 48 | at | Greensboro | 37 | @ USASC | |||
| Shenandoah | 27 | at | Methodist | 10 | @ USASC | |||
| North Carolina Wesleyan | 7 | at | Randolph-Macon | 49 | USASC | |||
| Hampden-Sydney | 48 | at | Wabash | 52 | @ NCA | |||
| Christopher Newport | 9 | at | Washington and Lee | 3 | NJAC | |||
| 9/10/2022 | Southern Virginia | 10 | at | Bridgewater VA | 58 | USASC | ||
| Randolph-Macon | 41 | at | Catholic | 7 | @ NEWMAC | |||
| Averett | 24 | at | Christopher Newport | 20 | @ NJAC | |||
| Muskingum | 31 | at | Ferrum | 3 | OAC | |||
| Methodist | 49 | at | Guilford | 16 | USASC | |||
| Widener | 31 | at | Hampden-Sydney | 27 | MidAC | |||
| Washington and Lee | 44 | at | Sewanee | 0 | @ SAA | |||
| North Carolina Wesleyan | 0 | at | Shenandoah | 45 | USASC | |||
| 9/17/2022 | Brevard | 6 | at | Averett | 23 | USASC | ||
| Huntingdon AL | 47 | at | Guilford | 7 | USASC | |||
| Greensboro | 28 | at | Hampden-Sydney | 70 | USASC | |||
| Ferrum | 38 | at | LaGrange | 44 | @ USASC | |||
| Shenandoah | 34 | at | Maryville | 29 | @ USASC | |||
| Washington and Lee | 37 | at | Methodist | 14 | @ USASC | |||
| Bridgewater VA | 48 | at | North Carolina Wesleyan | 7 | @ USASC | |||
| Southern Virginia | 20 | at | Randolph-Macon | 47 | USASC | |||
| 10/1/2022 | Hampden-Sydney | 17 | at | Bridgewater VA | 27 | |||
| Guilford | 19 | at | Randolph-Macon | 48 | ||||
| Ferrum | 0 | at | Shenandoah | 20 | ||||
| Averett | 0 | at | Washington and Lee | 31 | ||||
| 10/8/2022 | Randolph-Macon | 55 | at | Averett | 7 | |||
| Shenandoah | 17 | at | Bridgewater VA | 23 | ||||
| Hampden-Sydney | 35 | at | Ferrum | 16 | ||||
| Washington and Lee | 31 | at | Guilford | 6 | ||||
| 10/15/2022 | Washington and Lee | 17 | at | Ferrum | 7 | |||
| Averett | 26 | at | Hampden-Sydney | 37 | ||||
| Bridgewater VA | 7 | at | Randolph-Macon | 44 | ||||
| Guilford | 35 | at | Shenandoah | 38 | ||||
| 10/22/2022 | Averett | 16 | at | Bridgewater VA | 23 | |||
| Ferrum | 31 | at | Guilford | 17 | ||||
| Randolph-Macon | 35 | at | Shenandoah | 21 | ||||
| Hampden-Sydney | 44 | at | Washington and Lee | 43 | OT | |||
| 10/29/2022 | Shenandoah | 45 | at | Averett | 0 | |||
| Bridgewater VA | 52 | at | Ferrum | 28 | ||||
| Guilford | 21 | at | Hampden-Sydney | 28 | ||||
| Randolph-Macon | 35 | at | Washington and Lee | 21 | ||||
| 11/5/2022 | Guilford | 26 | at | Averett | 0 | |||
| Washington and Lee | 6 | at | Bridgewater VA | 13 | ||||
| Ferrum | 10 | at | Randolph-Macon | 52 | ||||
| Hampden-Sydney | 7 | at | Shenandoah | 23 | ||||
| 11/12/2022 | Averett | 24 | at | Ferrum | 20 | |||
| Bridgewater VA | 64 | at | Guilford | 22 | ||||
| Randolph-Macon | 38 | at | Hampden-Sydney | 17 | ||||
| Shenandoah | 16 | at | Washington and Lee | 14 | 3OT | |||
| 11/19/2022 | Cortland | 28 | at | Randolph-Macon | 35 | D3 Championship Round 1 | E8 | |
| 11/26/2022 | Randolph-Macon | 32 | at | Delaware Valley | 39 | D3 Playoffs Round 2 | @ MidAC |