| 9/3/2022 | North Carolina Wesleyan | 7 | at | Randolph-Macon (11-1) | 49 | at ODC | ||
| 9/10/2022 | North Carolina Wesleyan | 0 | at | Shenandoah (8-2) | 45 | at ODC | ||
| 9/17/2022 | Bridgewater VA (9-1) | 48 | at | North Carolina Wesleyan | 7 | ODC | ||
| 9/24/2022 | North Carolina Wesleyan | 14 | at | Southern Virginia (1-9,1-6) | 13 | |||
| 9/30/2022 | LaGrange (1-8,0-7) | 22 | at | North Carolina Wesleyan | 37 | |||
| 10/8/2022 | North Carolina Wesleyan | 0 | at | Belhaven (8-2,6-2) | 24 | |||
| 10/15/2022 | Methodist (5-5,4-3) | 34 | at | North Carolina Wesleyan | 33 | |||
| 10/22/2022 | North Carolina Wesleyan | 7 | at | Maryville (5-5,5-2) | 61 | |||
| 11/5/2022 | Huntingdon AL (9-2,7-0) | 34 | at | North Carolina Wesleyan | 17 | |||
| 11/12/2022 | North Carolina Wesleyan | 35 | at | Greensboro (1-9,1-6) | 14 |
| vs North Carolina Wesleyan | vs Other Opponents | North Carolina Wesleyan compared to OOs | |
| Record: | 7-3 | 51-41 | |
| Points Scored: | 34.40 | 30.34 | -4.06 |
| Points Allowed: | 15.70 | 27.51 | -11.81 |
| Margin: | 18.70 | 2.83 | -15.87 |
| Total Points: | 50.10 | 57.85 | -7.75 |