| 9/10/2022 | Muskingum | 31 | at | Ferrum (1-9) | 3 | at ODC | ||
| 9/17/2022 | Capital (0-10,0-9) | 7 | at | Muskingum | 37 | |||
| 9/24/2022 | Mount Union (14-1,9-0) | 59 | at | Muskingum | 0 | |||
| 10/1/2022 | Muskingum | 21 | at | Heidelberg (7-3,6-3) | 42 | |||
| 10/8/2022 | Otterbein (2-8,1-8) | 35 | at | Muskingum | 41 | 2OT | ||
| 10/15/2022 | Muskingum | 21 | at | Baldwin-Wallace (7-3,7-2) | 35 | |||
| 10/22/2022 | Muskingum | 23 | at | Ohio Northern (3-7,3-6) | 7 | |||
| 10/29/2022 | John Carroll (8-2,8-1) | 49 | at | Muskingum | 14 | |||
| 11/5/2022 | Muskingum | 27 | at | Wilmington (3-7,2-7) | 13 | |||
| 11/12/2022 | Marietta (6-4,5-4) | 38 | at | Muskingum | 23 |
| vs Muskingum | vs Other Opponents | Muskingum compared to OOs | |
| Record: | 5-5 | 46-49 | |
| Points Scored: | 28.80 | 25.49 | -3.31 |
| Points Allowed: | 23.80 | 24.91 | -1.11 |
| Margin: | 5.00 | 0.58 | -4.42 |
| Total Points: | 52.60 | 50.40 | 2.20 |