| 9/3/2022 | Berry (7-3) | 31 | at | Maryville | 24 | SAA | ||
| 9/10/2022 | Maryville | 10 | at | Centre (6-4) | 20 | at SAA | ||
| 9/17/2022 | Shenandoah (8-2) | 34 | at | Maryville | 29 | ODC | ||
| 9/24/2022 | Maryville | 37 | at | Greensboro (1-9,1-6) | 17 | |||
| 10/1/2022 | Huntingdon AL (9-2,7-0) | 42 | at | Maryville | 28 | |||
| 10/8/2022 | Maryville | 56 | at | LaGrange (1-8,0-7) | 17 | |||
| 10/15/2022 | Maryville | 45 | at | Southern Virginia (1-9,1-6) | 7 | |||
| 10/22/2022 | North Carolina Wesleyan (3-7,3-4) | 7 | at | Maryville | 61 | |||
| 10/29/2022 | Brevard (5-5,5-2) | 24 | at | Maryville | 21 | |||
| 11/12/2022 | Maryville | 25 | at | Belhaven (8-2,6-2) | 22 |
| vs Maryville | vs Other Opponents | Maryville compared to OOs | |
| Record: | 5-5 | 44-46 | |
| Points Scored: | 22.10 | 26.50 | 4.40 |
| Points Allowed: | 33.60 | 27.11 | 6.49 |
| Margin: | -11.50 | -0.61 | 10.89 |
| Total Points: | 55.70 | 53.61 | 2.09 |