| 9/3/2022 | Shenandoah (8-2) | 27 | at | Methodist | 10 | ODC | ||
| 9/10/2022 | Methodist | 49 | at | Guilford (2-8) | 16 | at ODC | ||
| 9/17/2022 | Washington and Lee (5-5) | 37 | at | Methodist | 14 | ODC | ||
| 9/24/2022 | Methodist | 38 | at | LaGrange (1-8,0-7) | 28 | |||
| 10/1/2022 | Belhaven (8-2,6-2) | 34 | at | Methodist | 27 | |||
| 10/8/2022 | Methodist | 20 | at | Brevard (5-5,5-2) | 22 | |||
| 10/15/2022 | Methodist | 34 | at | North Carolina Wesleyan (3-7,3-4) | 33 | |||
| 10/22/2022 | Huntingdon AL (9-2,7-0) | 38 | at | Methodist | 35 | |||
| 10/29/2022 | Methodist | 36 | at | Southern Virginia (1-9,1-6) | 23 | |||
| 11/5/2022 | Greensboro (1-9,1-6) | 23 | at | Methodist | 48 |
| vs Methodist | vs Other Opponents | Methodist compared to OOs | |
| Record: | 5-5 | 38-52 | |
| Points Scored: | 28.10 | 23.94 | -4.16 |
| Points Allowed: | 31.10 | 28.84 | 2.26 |
| Margin: | -3.00 | -4.90 | -1.90 |
| Total Points: | 59.20 | 52.78 | 6.42 |