| 9/3/2022 | Catholic | 37 | at | McDaniel (3-7) | 27 | at Cen | ||
| 9/10/2022 | Randolph-Macon (11-1) | 41 | at | Catholic | 7 | ODC | ||
| 9/17/2022 | Kean (3-7) | 33 | at | Catholic | 14 | NJAC | ||
| 9/24/2022 | Catholic | 7 | at | Christopher Newport (7-3) | 38 | at NJAC | ||
| 10/1/2022 | Catholic | 42 | at | MIT (3-6,1-5) | 7 | |||
| 10/8/2022 | Worcester Polytechnic (4-6,2-4) | 21 | at | Catholic | 24 | |||
| 10/15/2022 | Catholic | 24 | at | Coast Guard (3-7,1-5) | 17 | |||
| 10/22/2022 | Merchant Marine (6-3,4-2) | 33 | at | Catholic | 41 | |||
| 11/5/2022 | Catholic | 31 | at | Norwich (3-7,2-4) | 14 | |||
| 11/12/2022 | Springfield (9-3,6-0) | 35 | at | Catholic | 21 | |||
| 11/19/2022 | Catholic | 24 | at | Bridgewater State MA (7-4) | 34 | New England Bowl | at MSCAC |
| vs Catholic | vs Other Opponents | Catholic compared to OOs | |
| Record: | 5-6 | 54-48 | |
| Points Scored: | 27.27 | 24.50 | -2.77 |
| Points Allowed: | 24.73 | 21.83 | 2.90 |
| Margin: | 2.54 | 2.67 | 0.13 |
| Total Points: | 52.00 | 46.33 | 5.67 |