| 9/3/2022 | Hampden-Sydney (5-5) | 48 | at | Wabash | 52 | ODC | ||
| 9/10/2022 | North Central (15-0) | 56 | at | Wabash | 12 | CCIW | ||
| 9/17/2022 | Wabash | 48 | at | Wooster (6-4,4-4) | 14 | |||
| 9/24/2022 | Denison (8-2,6-2) | 45 | at | Wabash | 42 | |||
| 10/1/2022 | Wabash | 42 | at | Wittenberg (5-5,4-4) | 35 | |||
| 10/15/2022 | Ohio Wesleyan (6-4,6-2) | 24 | at | Wabash | 41 | |||
| 10/22/2022 | Wabash | 66 | at | Oberlin (0-10,0-8) | 20 | |||
| 10/29/2022 | Hiram (2-8,1-7) | 23 | at | Wabash | 59 | |||
| 11/5/2022 | Kenyon (3-7,2-6) | 25 | at | Wabash | 49 | |||
| 11/12/2022 | Wabash | 14 | at | DePauw (9-2,7-1) | 49 |
| vs Wabash | vs Other Opponents | Wabash compared to OOs | |
| Record: | 3-7 | 56-40 | |
| Points Scored: | 33.90 | 33.55 | -0.35 |
| Points Allowed: | 42.50 | 24.80 | 17.70 |
| Margin: | -8.60 | 8.75 | 17.35 |
| Total Points: | 76.40 | 58.35 | 18.05 |