| 9/3/2022 | Guilford (2-8) | 48 | at | Greensboro | 37 | ODC | ||
| 9/10/2022 | Greensboro | 14 | at | Gallaudet (7-3) | 31 | at ECFC | ||
| 9/17/2022 | Greensboro | 28 | at | Hampden-Sydney (5-5) | 70 | at ODC | ||
| 9/24/2022 | Maryville (5-5,5-2) | 37 | at | Greensboro | 17 | |||
| 9/30/2022 | Greensboro | 13 | at | Brevard (5-5,5-2) | 31 | |||
| 10/8/2022 | Southern Virginia (1-9,1-6) | 28 | at | Greensboro | 38 | |||
| 10/15/2022 | Belhaven (8-2,6-2) | 59 | at | Greensboro | 7 | |||
| 10/29/2022 | Greensboro | 0 | at | Huntingdon AL (9-2,7-0) | 42 | |||
| 11/5/2022 | Greensboro | 23 | at | Methodist (5-5,4-3) | 48 | |||
| 11/12/2022 | North Carolina Wesleyan (3-7,3-4) | 35 | at | Greensboro | 14 |
| vs Greensboro | vs Other Opponents | Greensboro compared to OOs | |
| Record: | 9-1 | 41-50 | |
| Points Scored: | 42.90 | 25.81 | -17.09 |
| Points Allowed: | 19.10 | 29.55 | -10.45 |
| Margin: | 23.80 | -3.74 | -27.54 |
| Total Points: | 62.00 | 55.36 | 6.64 |