| 9/3/2022 | St Scholastica (3-7) | 0 | at | Sewanee | 50 | MIA | ||
| 9/10/2022 | Washington and Lee (5-5) | 44 | at | Sewanee | 0 | ODC | ||
| 9/17/2022 | Westminster MO (1-9) | 6 | at | Sewanee | 41 | UMWAC | ||
| 10/1/2022 | Millsaps (3-7,2-5) | 30 | at | Sewanee | 27 | |||
| 10/8/2022 | Sewanee | 16 | at | Centre (6-4,4-3) | 35 | |||
| 10/15/2022 | Sewanee | 21 | at | Hendrix (3-7,2-5) | 48 | |||
| 10/22/2022 | Birmingham-Southern (7-3,5-2) | 47 | at | Sewanee | 3 | |||
| 10/29/2022 | Sewanee | 6 | at | Rhodes (5-5,3-4) | 33 | |||
| 11/5/2022 | Berry (7-3,5-2) | 63 | at | Sewanee | 14 | |||
| 11/12/2022 | Sewanee | 0 | at | Trinity TX (11-1,7-0) | 38 |
| vs Sewanee | vs Other Opponents | Sewanee compared to OOs | |
| Record: | 8-2 | 43-49 | |
| Points Scored: | 34.40 | 22.49 | -11.91 |
| Points Allowed: | 17.80 | 25.02 | -7.22 |
| Margin: | 16.60 | -2.53 | -19.13 |
| Total Points: | 52.20 | 47.51 | 4.69 |