| 9/1/2022 | Wilmington (3-7) | 52 | at | Southern Virginia | 27 | OAC | ||
| 9/10/2022 | Southern Virginia | 10 | at | Bridgewater VA (9-1) | 58 | at ODC | ||
| 9/17/2022 | Southern Virginia | 20 | at | Randolph-Macon (11-1) | 47 | at ODC | ||
| 9/24/2022 | North Carolina Wesleyan (3-7,3-4) | 14 | at | Southern Virginia | 13 | |||
| 10/8/2022 | Southern Virginia | 28 | at | Greensboro (1-9,1-6) | 38 | |||
| 10/15/2022 | Maryville (5-5,5-2) | 45 | at | Southern Virginia | 7 | |||
| 10/22/2022 | Southern Virginia | 6 | at | Belhaven (8-2,6-2) | 42 | |||
| 10/29/2022 | Methodist (5-5,4-3) | 36 | at | Southern Virginia | 23 | |||
| 11/5/2022 | Southern Virginia | 35 | at | LaGrange (1-8,0-7) | 21 | |||
| 11/12/2022 | Brevard (5-5,5-2) | 41 | at | Southern Virginia | 27 |
| vs Southern Virginia | vs Other Opponents | Southern Virginia compared to OOs | |
| Record: | 9-1 | 42-49 | |
| Points Scored: | 39.40 | 25.96 | -13.44 |
| Points Allowed: | 19.60 | 28.92 | -9.32 |
| Margin: | 19.80 | -2.96 | -22.76 |
| Total Points: | 59.00 | 54.88 | 4.12 |