| 9/2/2022 | Dean | 28 | at | Fitchburg State | 33 | @ MSCAC | ||
| 9/3/2022 | Misericordia | 14 | at | Alfred State | 17 | MidAC | ||
| Waynesburg | 52 | at | Gallaudet | 14 | TPAC | |||
| SUNY-Maritime | 10 | at | Hartwick | 31 | @ E8 | |||
| Wilkes | 48 | at | Keystone | 21 | MidAC | |||
| Castleton State | 7 | at | Plymouth State | 20 | @ MSCAC | |||
| 9/9/2022 | Dean | 55 | at | Nichols | 71 | @ CCF | ||
| Massachusetts Maritime | 14 | at | SUNY-Maritime | 17 | MSCAC | |||
| 9/10/2022 | Rochester | 30 | at | Alfred State | 17 | LL | ||
| UMass Dartmouth | 48 | at | Anna Maria | 63 | MSCAC | |||
| Fitchburg State | 0 | at | Castleton State | 48 | MSCAC | |||
| Greensboro | 14 | at | Gallaudet | 31 | USASC | |||
| Keystone | 20 | at | Misericordia | 38 | @ MidAC | |||
| 9/17/2022 | Curry | 33 | at | Dean | 25 | CCF | ||
| Alfred State | 17 | at | Husson | 23 | @ CCF | |||
| Anna Maria | 23 | at | Massachusetts Maritime | 14 | @ MSCAC | |||
| SUNY-Maritime | 13 | at | Merchant Marine | 48 | @ NEWMAC | |||
| Castleton State | 21 | at | Norwich | 26 | @ NEWMAC | |||
| Gallaudet | 34 | at | University of New England | 31 | @ CCF | |||
| Keystone | 20 | at | William Paterson | 27 | @ NJAC | |||
| 9/24/2022 | Defiance | 33 | at | Alfred State | 42 | HCA | ||
| Coast Guard | 66 | at | Anna Maria | 28 | NEWMAC | |||
| St Lawrence | 34 | at | Castleton State | 6 | LL | |||
| Hobart | 65 | at | Keystone | 6 | LL | |||
| Dean | 6 | at | MIT | 35 | @ NEWMAC | |||
| William Paterson | 14 | at | SUNY-Maritime | 3 | NJAC | |||
| 10/1/2022 | Alfred State | 30 | at | Anna Maria | 25 | |||
| Dean | 0 | at | Castleton State | 39 | ||||
| Gallaudet | 52 | at | Keystone | 44 | ||||
| 10/8/2022 | Keystone | 33 | at | Alfred State | 42 | |||
| Castleton State | 17 | at | Gallaudet | 20 | ||||
| Anna Maria | 41 | at | SUNY-Maritime | 27 | ||||
| 10/15/2022 | Keystone | 41 | at | Anna Maria | 39 | |||
| SUNY-Maritime | 33 | at | Castleton State | 36 | ||||
| Gallaudet | 26 | at | Dean | 23 | ||||
| 10/22/2022 | Dean | 36 | at | Alfred State | 35 | OT | ||
| SUNY-Maritime | 26 | at | Gallaudet | 24 | ||||
| Castleton State | 35 | at | Keystone | 20 | ||||
| 10/29/2022 | Alfred State | 13 | at | Castleton State | 37 | |||
| Anna Maria | 13 | at | Gallaudet | 27 | ||||
| Dean | 19 | at | SUNY-Maritime | 30 | ||||
| 11/5/2022 | Gallaudet | 36 | at | Alfred State | 22 | |||
| Anna Maria | 36 | at | Dean | 22 | ||||
| SUNY-Maritime | 20 | at | Keystone | 21 | ||||
| 11/12/2022 | Castleton State | 26 | at | Anna Maria | 27 | OT | ||
| Keystone | 45 | at | Dean | 44 | OT | |||
| Alfred State | 48 | at | SUNY-Maritime | 21 | ||||
| 11/19/2022 | Gallaudet | 0 | at | Delaware Valley | 59 | D3 Championship Round 1 | @ MidAC |