| 9/3/2022 | Waynesburg | 52 | at | Gallaudet (7-3) | 14 | at ECFC | ||
| 9/10/2022 | Case Western Reserve (6-4,6-3) | 45 | at | Waynesburg | 31 | |||
| 9/17/2022 | Geneva (3-7,3-6) | 30 | at | Waynesburg | 37 | |||
| 9/24/2022 | Waynesburg | 15 | at | Allegheny (3-7,3-6) | 31 | |||
| 10/8/2022 | Carnegie Mellon (11-1,8-0) | 27 | at | Waynesburg | 20 | |||
| 10/15/2022 | Waynesburg | 34 | at | Bethany WV (1-9,0-9) | 17 | |||
| 10/22/2022 | Waynesburg | 34 | at | Thiel (1-9,1-8) | 8 | |||
| 10/29/2022 | Westminster PA (7-3,7-2) | 30 | at | Waynesburg | 10 | |||
| 11/5/2022 | Waynesburg | 16 | at | St Vincent (5-5,5-4) | 53 | |||
| 11/12/2022 | Washington & Jefferson (9-2,7-2) | 56 | at | Waynesburg | 0 |
| vs Waynesburg | vs Other Opponents | Waynesburg compared to OOs | |
| Record: | 6-4 | 47-46 | |
| Points Scored: | 31.10 | 23.54 | -7.56 |
| Points Allowed: | 24.90 | 25.82 | -0.92 |
| Margin: | 6.20 | -2.28 | -8.48 |
| Total Points: | 56.00 | 49.36 | 6.64 |