| 9/3/2022 | Wilkes | 48 | at | Keystone (3-7) | 21 | at ECFC | ||
| 9/17/2022 | Widener (3-7,2-6) | 20 | at | Wilkes | 44 | |||
| 9/24/2022 | Wilkes | 19 | at | Lebanon Valley (5-6,5-4) | 24 | |||
| 10/1/2022 | Albright (0-10,0-8) | 0 | at | Wilkes | 27 | |||
| 10/8/2022 | Wilkes | 35 | at | Alvernia (3-7,2-6) | 14 | |||
| 10/15/2022 | Misericordia (3-7,2-6) | 0 | at | Wilkes | 28 | |||
| 10/22/2022 | Wilkes | 14 | at | Delaware Valley (12-1,8-0) | 27 | |||
| 10/29/2022 | Lycoming (4-6,4-5) | 7 | at | Wilkes | 24 | |||
| 11/5/2022 | Wilkes | 0 | at | Stevenson (8-3,6-2) | 28 | |||
| 11/12/2022 | King's (8-3,7-2) | 42 | at | Wilkes | 58 |
| vs Wilkes | vs Other Opponents | Wilkes compared to OOs | |
| Record: | 3-7 | 46-50 | |
| Points Scored: | 18.30 | 22.04 | 3.74 |
| Points Allowed: | 29.70 | 24.33 | 5.37 |
| Margin: | -11.40 | -2.29 | 9.11 |
| Total Points: | 48.00 | 46.37 | 1.63 |