| 9/2/2022 | Nichols | 30 | at | Westfield State (2-8) | 29 | at MSCAC | ||
| 9/9/2022 | Dean (1-9) | 55 | at | Nichols | 71 | ECFC | ||
| 9/17/2022 | Coast Guard (3-7) | 33 | at | Nichols | 37 | NEWMAC | ||
| 9/24/2022 | Nichols | 20 | at | Hartwick (2-8) | 28 | at E8 | ||
| 10/1/2022 | Western New England (4-6,3-3) | 47 | at | Nichols | 14 | |||
| 10/8/2022 | Nichols | 7 | at | Endicott (10-1,6-0) | 52 | |||
| 10/15/2022 | University of New England (5-5,3-3) | 31 | at | Nichols | 12 | |||
| 10/22/2022 | Nichols | 21 | at | Salve Regina (6-4,3-3) | 42 | |||
| 11/5/2022 | Nichols | 14 | at | Husson (5-6,4-2) | 27 | |||
| 11/12/2022 | Curry (3-7,1-5) | 28 | at | Nichols | 49 |
| vs Nichols | vs Other Opponents | Nichols compared to OOs | |
| Record: | 6-4 | 35-57 | |
| Points Scored: | 37.20 | 21.27 | -15.93 |
| Points Allowed: | 27.50 | 25.54 | 1.96 |
| Margin: | 9.70 | -4.27 | -13.97 |
| Total Points: | 64.70 | 46.81 | 17.89 |