| 9/3/2022 | Defiance | 0 | at | Mount Union (14-1) | 65 | at OAC | ||
| 9/17/2022 | Kalamazoo (3-7) | 42 | at | Defiance | 23 | MIAA | ||
| 9/24/2022 | Defiance | 33 | at | Alfred State (5-5) | 42 | at ECFC | ||
| 10/1/2022 | Hanover (5-5,5-2) | 37 | at | Defiance | 20 | |||
| 10/8/2022 | Defiance | 35 | at | Mt St Joseph (10-1,7-0) | 55 | |||
| 10/15/2022 | Defiance | 19 | at | Franklin (4-6,4-3) | 48 | |||
| 10/22/2022 | Anderson (1-9,1-6) | 22 | at | Defiance | 32 | |||
| 10/29/2022 | Defiance | 35 | at | Rose-Hulman (6-4,6-1) | 76 | |||
| 11/5/2022 | Manchester (1-9,0-7) | 21 | at | Defiance | 24 | |||
| 11/12/2022 | Defiance | 17 | at | Bluffton (2-8,2-5) | 14 |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 7-3 | 44-52 | |
| Points Scored: | 42.20 | 28.06 | -14.14 |
| Points Allowed: | 23.80 | 30.06 | -6.26 |
| Margin: | 18.40 | -2.00 | -20.40 |
| Total Points: | 66.00 | 58.12 | 7.88 |