| 9/3/2022 | Misericordia | 14 | at | Alfred State (5-5) | 17 | at ECFC | ||
| 9/10/2022 | Keystone (3-7) | 20 | at | Misericordia | 38 | ECFC | ||
| 9/17/2022 | Misericordia | 27 | at | Albright (0-10,0-8) | 21 | |||
| 9/24/2022 | Misericordia | 0 | at | Delaware Valley (12-1,8-0) | 41 | |||
| 10/1/2022 | Fairleigh Dickinson-Florham (6-5,4-4) | 28 | at | Misericordia | 14 | |||
| 10/8/2022 | Lebanon Valley (5-6,5-4) | 47 | at | Misericordia | 12 | |||
| 10/15/2022 | Misericordia | 0 | at | Wilkes (7-3,6-3) | 28 | |||
| 10/29/2022 | Stevenson (8-3,6-2) | 44 | at | Misericordia | 7 | |||
| 11/5/2022 | Misericordia | 0 | at | King's (8-3,7-2) | 14 | |||
| 11/12/2022 | Lycoming (4-6,4-5) | 14 | at | Misericordia | 21 |
| vs Misericordia | vs Other Opponents | Misericordia compared to OOs | |
| Record: | 7-3 | 51-46 | |
| Points Scored: | 27.40 | 23.77 | -3.63 |
| Points Allowed: | 13.30 | 23.25 | -9.95 |
| Margin: | 14.10 | 0.52 | -13.58 |
| Total Points: | 40.70 | 47.02 | -6.32 |