| 9/3/2022 | Castleton State (5-5) | 7 | at | Plymouth State | 20 | ECFC | ||
| 9/10/2022 | Plymouth State | 17 | at | Husson (5-6) | 0 | at CCF | ||
| 9/17/2022 | Bridgewater State MA (7-4,6-2) | 34 | at | Plymouth State | 41 | |||
| 10/1/2022 | Plymouth State | 14 | at | Framingham State (5-5,4-4) | 9 | |||
| 10/8/2022 | Western Connecticut (7-3,6-2) | 34 | at | Plymouth State | 27 | |||
| 10/15/2022 | Plymouth State | 42 | at | Fitchburg State (1-9,0-8) | 7 | |||
| 10/22/2022 | Plymouth State | 56 | at | Worcester State (1-9,1-7) | 21 | |||
| 10/29/2022 | Westfield State (2-8,2-6) | 22 | at | Plymouth State | 31 | |||
| 11/5/2022 | Plymouth State | 21 | at | Massachusetts Maritime (3-7,3-5) | 7 | |||
| 11/12/2022 | UMass Dartmouth (9-2,8-0) | 46 | at | Plymouth State | 21 | |||
| 11/19/2022 | Plymouth State | 21 | at | Husson (5-6) | 20 | New England Bowl | at CCF |
| vs Plymouth State | vs Other Opponents | Plymouth State compared to OOs | |
| Record: | 2-9 | 48-53 | |
| Points Scored: | 18.82 | 23.72 | 4.90 |
| Points Allowed: | 28.27 | 26.54 | 1.73 |
| Margin: | -9.45 | -2.82 | 6.63 |
| Total Points: | 47.09 | 50.26 | -3.17 |