| 9/3/2022 | Rochester | 28 | at | Utica (10-2) | 43 | at E8 | ||
| 9/10/2022 | Rochester | 30 | at | Alfred State (5-5) | 17 | at ECFC | ||
| 9/17/2022 | Brockport State (7-3) | 23 | at | Rochester | 3 | E8 | ||
| 10/1/2022 | Rensselaer (8-3,5-1) | 31 | at | Rochester | 3 | |||
| 10/8/2022 | Rochester | 10 | at | Ithaca (12-1,6-0) | 56 | |||
| 10/15/2022 | Buffalo State (0-10,0-6) | 6 | at | Rochester | 12 | |||
| 10/22/2022 | Rochester | 7 | at | Union NY (6-4,3-3) | 27 | |||
| 10/29/2022 | St Lawrence (4-6,2-4) | 35 | at | Rochester | 31 | |||
| 11/5/2022 | Hartwick (2-8) | 13 | at | Rochester | 19 | E8 | ||
| 11/12/2022 | Rochester | 7 | at | Hobart (7-4,4-2) | 27 |
| vs Rochester | vs Other Opponents | Rochester compared to OOs | |
| Record: | 7-3 | 54-43 | |
| Points Scored: | 27.80 | 24.39 | -3.41 |
| Points Allowed: | 15.00 | 22.34 | -7.34 |
| Margin: | 12.80 | 2.05 | -10.75 |
| Total Points: | 42.80 | 46.73 | -3.93 |