| 9/3/2022 | Husson | 14 | at | UMass Dartmouth (9-2) | 35 | at MSCAC | ||
| 9/10/2022 | Plymouth State (9-2) | 17 | at | Husson | 0 | MSCAC | ||
| 9/17/2022 | Alfred State (5-5) | 17 | at | Husson | 23 | ECFC | ||
| 9/24/2022 | Husson | 7 | at | Springfield (9-3) | 49 | at NEWMAC | ||
| 10/1/2022 | Husson | 0 | at | Endicott (10-1,6-0) | 20 | |||
| 10/8/2022 | University of New England (5-5,3-3) | 14 | at | Husson | 31 | |||
| 10/15/2022 | Husson | 38 | at | Curry (3-7,1-5) | 26 | |||
| 10/29/2022 | Western New England (4-6,3-3) | 17 | at | Husson | 27 | |||
| 11/5/2022 | Nichols (4-6,1-5) | 14 | at | Husson | 27 | |||
| 11/12/2022 | Husson | 10 | at | Salve Regina (6-4,3-3) | 24 | |||
| 11/19/2022 | Plymouth State (9-2) | 21 | at | Husson | 20 | New England Bowl | MSCAC |
| vs Husson | vs Other Opponents | Husson compared to OOs | |
| Record: | 6-5 | 65-38 | |
| Points Scored: | 23.09 | 29.49 | 6.40 |
| Points Allowed: | 17.91 | 23.63 | -5.72 |
| Margin: | 5.18 | 5.86 | 0.68 |
| Total Points: | 41.00 | 53.12 | -12.12 |