| 9/3/2022 | Endicott (10-1) | 27 | at | St Lawrence | 0 | CCF | ||
| 9/10/2022 | St Lawrence | 30 | at | Norwich (3-7) | 19 | at NEWMAC | ||
| 9/16/2022 | Morrisville (7-4) | 17 | at | St Lawrence | 15 | E8 | ||
| 9/24/2022 | St Lawrence | 34 | at | Castleton State (5-5) | 6 | at ECFC | ||
| 10/8/2022 | Union NY (6-4,3-3) | 44 | at | St Lawrence | 7 | |||
| 10/15/2022 | St Lawrence | 0 | at | Ithaca (12-1,6-0) | 40 | |||
| 10/22/2022 | Hobart (7-4,4-2) | 31 | at | St Lawrence | 10 | |||
| 10/29/2022 | St Lawrence | 35 | at | Rochester (3-7,1-5) | 31 | |||
| 11/5/2022 | St Lawrence | 6 | at | Rensselaer (8-3,5-1) | 10 | |||
| 11/12/2022 | Buffalo State (0-10,0-6) | 7 | at | St Lawrence | 31 |
| vs St Lawrence | vs Other Opponents | St Lawrence compared to OOs | |
| Record: | 6-4 | 55-42 | |
| Points Scored: | 23.20 | 23.99 | 0.79 |
| Points Allowed: | 16.80 | 18.84 | -2.04 |
| Margin: | 6.40 | 5.15 | -1.25 |
| Total Points: | 40.00 | 42.83 | -2.83 |