| 9/2/2022 | Alfred | 6 | at | Hobart | 36 | @ LL | ||
| 9/3/2022 | Framingham State | 7 | at | Brockport State | 27 | MSCAC | ||
| Wittenberg | 28 | at | Cortland | 48 | NCA | |||
| SUNY-Maritime | 10 | at | Hartwick | 31 | ECFC | |||
| Kean | 0 | at | Morrisville | 10 | NJAC | |||
| Buffalo State | 21 | at | St John Fisher | 62 | LL | |||
| Rochester | 28 | at | Utica | 43 | LL | |||
| 9/10/2022 | Mt St Joseph | 43 | at | Alfred | 37 | HCA | ||
| New Jersey | 7 | at | Cortland | 63 | NJAC | |||
| St John Fisher | 20 | at | Framingham State | 31 | @ MSCAC | |||
| King's | 17 | at | Hartwick | 10 | MidAC | |||
| Brockport State | 0 | at | Ithaca | 24 | @ LL | |||
| Hobart | 13 | at | Morrisville | 24 | LL | |||
| Kean | 15 | at | Utica | 21 | NJAC | |||
| 9/16/2022 | Morrisville | 17 | at | St Lawrence | 15 | @ LL | ||
| 9/17/2022 | Cortland | 66 | at | Buffalo State | 7 | @ LL | ||
| St John Fisher | 0 | at | Hobart | 17 | @ LL | |||
| Alfred | 3 | at | Ithaca | 52 | @ LL | |||
| Brockport State | 23 | at | Rochester | 3 | @ LL | |||
| Utica | 23 | at | Western New England | 21 | @ CCF | |||
| 9/24/2022 | Kalamazoo | 23 | at | Alfred | 31 | MIAA | ||
| Morrisville | 31 | at | Buffalo State | 10 | @ LL | |||
| Nichols | 20 | at | Hartwick | 28 | CCF | |||
| Rensselaer | 0 | at | St John Fisher | 3 | LL | |||
| Utica | 31 | at | Union NY | 24 | @ LL | |||
| 10/1/2022 | St John Fisher | 0 | at | Brockport State | 25 | |||
| Morrisville | 7 | at | Cortland | 28 | ||||
| Hartwick | 7 | at | Utica | 57 | ||||
| 10/8/2022 | Cortland | 42 | at | Brockport State | 24 | |||
| Alfred | 21 | at | Hartwick | 6 | ||||
| Morrisville | 10 | at | St John Fisher | 3 | ||||
| 10/15/2022 | St John Fisher | 21 | at | Alfred | 7 | |||
| Hartwick | 7 | at | Cortland | 69 | ||||
| Brockport State | 21 | at | Utica | 35 | ||||
| 10/22/2022 | Brockport State | 35 | at | Hartwick | 14 | |||
| Alfred | 0 | at | Morrisville | 36 | ||||
| Cortland | 48 | at | Utica | 21 | ||||
| 10/29/2022 | Cortland | 31 | at | Alfred | 8 | |||
| Buffalo State | 2 | at | Brockport State | 54 | LL | |||
| Utica | 20 | at | Morrisville | 17 | ||||
| Hartwick | 26 | at | St John Fisher | 44 | ||||
| 11/5/2022 | Morrisville | 3 | at | Brockport State | 17 | |||
| St John Fisher | 14 | at | Cortland | 56 | ||||
| Hartwick | 13 | at | Rochester | 19 | @ LL | |||
| Alfred | 16 | at | Utica | 65 | ||||
| 11/12/2022 | Brockport State | 16 | at | Alfred | 7 | |||
| Cortland | 17 | vs | Ithaca | 34 | Bronx NY | vs LL | ||
| Hartwick | 12 | at | Morrisville | 38 | ||||
| Utica | 35 | at | St John Fisher | 21 | ||||
| 11/19/2022 | Westminster PA | at | Brockport State | CCD | TPAC | |||
| Cortland | 28 | at | Randolph-Macon | 35 | D3 Championship Round 1 | @ ODC | ||
| Morrisville | 6 | at | Rensselaer | 10 | @ LL | |||
| Utica | 17 | at | Susquehanna | 10 | D3 Championship Round 1 | @ Cen | ||
| 11/26/2022 | Utica | 7 | at | Mount Union | 45 | D3 Playoffs Round 2 | @ OAC |