| 9/3/2022 | Ithaca | 51 | at | Bridgewater State MA (7-4) | 14 | at MSCAC | ||
| 9/10/2022 | Brockport State (7-3) | 0 | at | Ithaca | 24 | E8 | ||
| 9/17/2022 | Alfred (2-8) | 3 | at | Ithaca | 52 | E8 | ||
| 10/1/2022 | Ithaca | 31 | at | Hobart (7-4,4-2) | 7 | |||
| 10/8/2022 | Rochester (3-7,1-5) | 10 | at | Ithaca | 56 | |||
| 10/15/2022 | St Lawrence (4-6,2-4) | 0 | at | Ithaca | 40 | |||
| 10/21/2022 | Ithaca | 51 | at | Buffalo State (0-10,0-6) | 10 | |||
| 10/29/2022 | Rensselaer (8-3,5-1) | 10 | at | Ithaca | 13 | |||
| 11/5/2022 | Ithaca | 31 | at | Union NY (6-4,3-3) | 28 | |||
| 11/12/2022 | Cortland (9-2) | 17 | vs | Ithaca | 34 | Bronx NY | E8 | |
| 11/19/2022 | UMass Dartmouth (9-2) | 20 | at | Ithaca | 63 | D3 Championship Round 1 | MSCAC | |
| 11/26/2022 | Springfield (9-3) | 20 | at | Ithaca | 31 | D3 Playoffs Round 2 | NEWMAC | |
| 12/3/2022 | Ithaca | 7 | at | North Central (15-0) | 48 | D3 Quarterfinals | at CCIW |
| vs Ithaca | vs Other Opponents | Ithaca compared to OOs | |
| Record: | 1-12 | 85-44 | |
| Points Scored: | 14.38 | 30.49 | 16.11 |
| Points Allowed: | 37.23 | 18.34 | 18.89 |
| Margin: | -22.85 | 12.15 | 35.00 |
| Total Points: | 51.61 | 48.83 | 2.78 |