| 9/3/2022 | Framingham State | 7 | at | Brockport State (7-3) | 27 | at E8 | ||
| 9/10/2022 | St John Fisher (4-6) | 20 | at | Framingham State | 31 | E8 | ||
| 9/17/2022 | Framingham State | 21 | at | UMass Dartmouth (9-2,8-0) | 46 | |||
| 9/24/2022 | Framingham State | 14 | at | Westfield State (2-8,2-6) | 11 | |||
| 10/1/2022 | Plymouth State (9-2,6-2) | 14 | at | Framingham State | 9 | |||
| 10/8/2022 | Fitchburg State (1-9,0-8) | 0 | at | Framingham State | 47 | |||
| 10/15/2022 | Framingham State | 14 | at | Western Connecticut (7-3,6-2) | 35 | |||
| 10/29/2022 | Massachusetts Maritime (3-7,3-5) | 10 | at | Framingham State | 34 | |||
| 11/5/2022 | Framingham State | 19 | at | Bridgewater State MA (7-4,6-2) | 20 | |||
| 11/11/2022 | Worcester State (1-9,1-7) | 16 | at | Framingham State | 21 |
| vs Framingham State | vs Other Opponents | Framingham State compared to OOs | |
| Record: | 5-5 | 45-48 | |
| Points Scored: | 19.90 | 24.32 | 4.42 |
| Points Allowed: | 21.70 | 26.31 | -4.61 |
| Margin: | -1.80 | -1.99 | -0.19 |
| Total Points: | 41.60 | 50.63 | -9.03 |